In all analyses statistical significance was set at p Salt sensitive: Participants with SBP being at least 5 mmHg higher after HS intake compared to the values after the LS intake; Salt resistant: Participants whose SBP differed by Statistical investigation General linear activities have been used in linear regression analysis (Pearson’s Roentgen correlation) to assess the fresh new relationship off urinary Na + and you may K + removal that have SBP. To possess Figs. dos and you may 3, two-means ANOVA with Tukey’s blog post hoc are did examine SBP one of the groups defined based on urinary Na + and you will K + removal. In order to quantify the effectiveness of growing urinary Na + and K + excretion in accordance with SBP, Cohn’s Impact Dimensions are computed. In the Figs. 4 and 5 generalized Pearson’s R correlation are did to evaluate the new relationship of one’s urinary Na + :K + excretion ratio with SBP. During the Fig. six study have been analyzed by a good three-means ANOVA plus the pairwise evaluations were made having fun with Tukey’s article hoc attempt. From inside the Fig. seven relative volume shipments was reviewed having fun with a good Gaussian complement studies. 05 (GraphPad prism app, adaptation 8). Analysis are displayed once the suggest ± SD. Baseline systolic blood pressure (SBP) at screening on regular diet (a) according to changes potassium excretion for salt sensitive (n = 186) and salt resistant (n = 222) group, slope for salt sensitive and salt resistant group is indicated for the potassium excretion range Baseline systolic blood pressure (SBP) at screening on regular diet (a) according to changes sodium excretion of 99 g/time, values shown just like the suggest ± SD. b Relationship out-of baseline SBP (situated adjustable) along side whole variety urinary potassium excretion (separate variable), (Pearson’s Roentgen 2 to possess salt painful and sensitive = 0.001 and sodium unwilling = 0.008), in salt sensitive and painful (letter = 186) and you can sodium unwilling (n = 222) anybody. Baseline SBP according to urinary sodium in order to potassium excretion ratio (Na + /K + ) (a) correlation out-of standard SBP (mainly based varying) along the whole set of urinary Na + /K + excretion (separate changeable), (Pearson’s Roentgen dos to possess sodium delicate = 0.0004 and you may sodium resistant = 0.0016) (b) baseline SBP predicated on changes in salt excretion and you can potassium excretion variety into the salt delicate (letter = 186) and you may salt unwilling (n = 222) anybody on testing to their normal diet, beliefs revealed as the imply ± SD. Analysis was indeed assessed by about three-way ANOVA that have pairwise investigations followed by Tukey’s post hoc decide to try. Relationship regarding SBP opinions along the entire range of urinary salt in order to potassium removal (Na + /K + ) proportion into the salt painful and sensitive (n = 71) and you will sodium resistant (letter = 119) people who have diet input of one’s Losing weight Methods to End Blood pressure levels (DASH) (a) high salt (HS), (Pearson’s R 2 getting salt sensitive = 0.04 and you may sodium unwilling = 0.04) (b) lower sodium (LS) diet plan, (Pearson’s Roentgen 2 getting salt sensitive and painful = 0.02 and sodium resistant = 0.00002).

In all analyses statistical significance was set at p < 0

Salt sensitive: Participants with SBP being at least 5 mmHg higher after HS intake compared to the values after the LS intake; Salt resistant: Participants whose SBP differed by <5 mmHg between HS and LS intakes; Independent variables: Urinary Na + , Urinary K + and Na + :K + excretion ratio; Dependent variable: SBP; Categorical variable: Participants were categorized into groups on the basis of increments of 1 g/day in urinary Na + and K + excretion to evaluate the linear trends

Statistical investigation

General linear activities have been used in linear regression analysis (Pearson’s Roentgen correlation) to assess the fresh new relationship off urinary Na + and you may K + removal that have SBP. To possess Figs. dos and you may 3, two-means ANOVA with Tukey’s blog post hoc are did examine SBP one of the groups defined based on urinary Na + and you will K + removal. In order to quantify the effectiveness of growing urinary Na + and K + excretion in accordance with SBP, Cohn’s Impact Dimensions are computed. In the Figs. 4 and 5 generalized Pearson’s R correlation are did to evaluate the new relationship of one’s urinary Na + :K + excretion ratio with SBP. During the Fig. six study have been analyzed by a good three-means ANOVA plus the pairwise evaluations were made having fun with Tukey’s article hoc attempt. From inside the Fig. seven relative volume shipments was reviewed having fun with a good Gaussian complement studies. 05 (GraphPad prism app, adaptation 8). Analysis are displayed once the suggest ± SD.

Baseline systolic blood pressure (SBP) at screening on regular diet (a) according to changes potassium excretion for salt sensitive (n = 186) and salt resistant (n = 222) group, slope for salt sensitive and salt resistant group is indicated for the potassium excretion range <1–1

Baseline systolic blood pressure (SBP) at screening on regular diet (a) according to changes sodium excretion of <5 g/day, in salt sensitive (n = 154) and salt resistant (n = 180) group, slope of the for salt sensitive group is indicated for the sodium excretion ranges of <2–2.99 g/day, 3–3.99 g/day and 4–4.99 g/day (b) Correlation of baseline SBP (dependent variable) across the entire range of urinary sodium excretion (independent variable), (Pearson's R 2 for salt sensitive = 0.02 and for salt resistant = 0.02), in salt sensitive (n = 186) and salt resistant (n = 222) individuals.

99 g/time, values shown just like the suggest ± SD. b Relationship out-of baseline SBP (situated adjustable) along side whole variety urinary potassium excretion (separate variable), (Pearson’s Roentgen 2 to possess salt painful and sensitive = 0.001 and sodium unwilling = 0.008), in salt sensitive and painful (letter = 186) and you can sodium unwilling (n = 222) anybody.

Baseline SBP according to urinary this hyperlink sodium in order to potassium excretion ratio (Na + /K + ) (a) correlation out-of standard SBP (mainly based varying) along the whole set of urinary Na + /K + excretion (separate changeable), (Pearson’s Roentgen dos to possess sodium delicate = 0.0004 and you may sodium resistant = 0.0016) (b) baseline SBP predicated on changes in salt excretion and you can potassium excretion variety into the salt delicate (letter = 186) and you may salt unwilling (n = 222) anybody on testing to their normal diet, beliefs revealed as the imply ± SD. Analysis was indeed assessed by about three-way ANOVA that have pairwise investigations followed by Tukey’s post hoc decide to try.

Relationship regarding SBP opinions along the entire range of urinary salt in order to potassium removal (Na + /K + ) proportion into the salt painful and sensitive (n = 71) and you will sodium resistant (letter = 119) people who have diet input of one’s Losing weight Methods to End Blood pressure levels (DASH) (a) high salt (HS), (Pearson’s R 2 getting salt sensitive = 0.04 and you may sodium unwilling = 0.04) (b) lower sodium (LS) diet plan, (Pearson’s Roentgen 2 getting salt sensitive and painful = 0.02 and sodium resistant = 0.00002).

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